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ea0090rc9.1 | Rapid Communications 9: Adrenal and Cardiovascular Endocrinology 2 | ECE2023

Symptoms of glucocorticoid-induced adrenal insufficiency – A systematic evaluation of clinician- and patient-reported symptoms and their rated relevance

Lund Marie Louise , Bjorner Jakob Bue , Al-Jorani Hajir , Boesen Victor Brun , Dreyer Anja Fenger , Boggild Hansen Simon , Jorgensen Nanna Thurmann , Klose Marianne , Tei Randi , Watt Torquil , Feldt-Rasmussen Ulla , Borresen Stina Willemoes

Context: Glucocorticoid-induced adrenal insufficiency is the most frequent type of adrenal insufficiency, but its symptomatology has not been thoroughly studied.Objective: To describe the predominant symptoms experienced by patients with glucocorticoid-induced adrenal insufficiency and rate these symptoms significance for patients perceived need for supplemental hydrocortisone stress dose.Methods: The 80 symptoms in the...

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ea0090p19 | Adrenal and Cardiovascular Endocrinology | ECE2023

RESCUE: Effect of supplemental hydrocortisone during stress in glucocorticoid-induced adrenal insufficiency; A study protocol for a multicentre, randomised, double blinded, placebo-controlled clinical trial

Willemoes Borresen Stina , Boggild Hansen Simon , Al-Jorani Hajir , Sofie Bislev Lise , Bue Bjorner Jakob , Brun Boesen Victor , Lehmann Christensen Louise , Fenger Dreyer Anja , Glintborg Dorte , Christian Jensen Richard , Thurmann Jorgensen Nanna , Klose Marianne , Louise Lund Marie , Stankovic Jelena , Tei Randi , Watt Torquil , Otto Lunde Jorgensen Jens , Skovsager Andersen Marianne , Feldt-Rasmussen Ulla

Background: Long-term, low-dose prednisolone treatment (≤5mg/day) is associated with adrenal insufficiency in >33% of patients. Nevertheless, the clinical consequences of glucocorticoid-induced adrenal insufficiency in patients receiving ongoing low-dose glucocorticoid treatment are unknown. Current clinical guidelines do not recommend routine evaluation of adrenal function during low-dose glucocorticoid treatment, and patients are not routinely instructed to increase gl...

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ea0090p564 | Adrenal and Cardiovascular Endocrinology | ECE2023

Glucocorticoid-induced adrenal insufficiency: Identification of diagnostic and prognostic biomarkers based on two randomized controlled trials - REFINE

Boggild Hansen Simon , Fenger Dreyer Anja , Willemoes Borresen Stina , Al-Jorani Hajir , Sofie Bislev Lise , Brun Boesen Victor , Lehmann Christensen Louise , Glintborg Dorte , Christian Jensen Richard , Thurmann Jorgensen Nanna , Klose Marianne , Louise Lund Marie , Stankovic Jelena , Tei Randi , Watt Torquil , M Stewart Paul , Andersen Marianne , Feldt-Rasmussen Ulla , Otto Jorgensen Jens

Background: The risk and course of glucocorticoid-induced adrenal insufficiency (GIA) are unclear and current evidence is retrospective and based on small and selected study populations. However, the prevalence of glucocorticoid use is at least 3 %, which underscores the need for unbiased and prospective assessment of the prevalence and clinical consequences of GIA.Objectives: To identify biomarkers of GIA as regards diagnosis, prognosis and responsivene...

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Endocrine Abstracts

Symptoms of glucocorticoid-induced adrenal insufficiency – A systematic evaluation of clinician- and patient-reported symptoms and their rated relevance

RESCUE: Effect of supplemental hydrocortisone during stress in glucocorticoid-induced adrenal insufficiency; A study protocol for a multicentre, randomised, double blinded, placebo-controlled clinical trial

Glucocorticoid-induced adrenal insufficiency: Identification of diagnostic and prognostic biomarkers based on two randomized controlled trials - REFINE

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